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epTau 217

Detects a core phosphorylated tau biomarker highly associated with early Alzheimer’s pathology.
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GFAP

Measures glial fibrillary acidic protein, an astrocyte-derived marker linked to TBI and other CNS conditions.
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Mouse NF-L

Enables ultra-sensitive, low-volume measurement of mouse neurofilament light (NF-L) across plasma, serum, and CSF to support longitudinal preclinical studies.
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Mouse pTau 217

Enables ultra-sensitive, low-volume measurement of mouse pTau 217 in plasma and CSF to support longitudinal preclinical studies.
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Biomarker Assays for Neurological Disease

The SPEAR platform currently supports a portfolio of assays optimized for research in neurological diseases, including Alzheimer’s disease (AD), traumatic brain injury (TBI), multiple sclerosis (MS), and Amyotrophic lateral sclerosis (ALS). As part of workflows designed to identify and validate biomarkers, these assays provide sensitive, reliable quantification of targets associated with axonal damage, astrocyte activation, and tau pathology.

Kit Pairing

Assay Kit & Reaction Kit

Each SPEAR UltraDetect Assay Kits requires a universal SPEAR UltraDetect Reaction Kit

Each SPEAR UltraDetect Reaction Kit can support up to 4 SPEAR Ultra Detect Assay Kits

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Kit Throughput

Each SPEAR UltraDetect Assay Kit can support 1 96-well plate

Each SPEAR UltraDetect Reaction Kit can support up to 4 96-well plates or 1 384-well plate

Benefits of SPEAR Assays

Attomolar biomarker measurement with 1 uL of diluted sample.

Two-factor authentication ensures target-specific signal.
No false positives from non-specific binding to a solid surface.

Easy-to-automate workflow with <5% mean CV from 1 µl of diluted sample.

Highly consistent measurement across different qPCR platforms and formats.

Discover SPEAR Assays

As the first ultrasensitive assay to combine a fully homogeneous format with two-factor authentication, SPEAR UltraDetect sets a new standard in protein biomarker detection.

 

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