Mouse pTau 217 for Preclinical Alzheimer’s Disease Research
Phosphorylated tau 217 is an important biomarker in Alzheimer’s disease research and is widely studied for its association with tau pathology and disease progression. Measuring pTau 217 in mouse models can help researchers bridge preclinical and human biomarker studies, evaluate disease biology, and monitor therapeutic response over time.
Mouse models are widely used to study tau pathology, neurodegeneration, disease progression, and therapeutic response. However, preclinical biomarker studies are often constrained by limited sample volume, especially when researchers need to evaluate multiple timepoints or preserve sample for additional analyses.
SPEAR UltraDetect™ Mouse pTau 217 helps address these challenges with low-volume sample input and sensitive measurement in EDTA plasma and CSF.
Ultra-Sensitive, Low-Volume Mouse pTau 217 Measurement in Plasma and CSF
SPEAR UltraDetect™ Mouse pTau 217 supports ultra-sensitive pTau 217 measurement across key mouse sample types, including plasma and CSF.
In commercially sourced samples from young mice, pTau 217 was measured across plasma and CSF* using 1 µL diluted sample. This flexibility supports preclinical studies where sample volume is limited and researchers need to evaluate pTau 217 across multiple matrices.
By combining ultra-sensitivity with low sample input, SPEAR UltraDetect™ Mouse pTau 217 helps researchers preserve valuable mouse samples, support longitudinal study designs, and measure pTau 217 across multiple sample types used in preclinical Alzheimer’s disease research.
SPEAR UltraDetect™ Mouse pTau 217
[1 µL diluted sample]
*Endogenous levels for CSF were tested for reference only. Full verification of assay performance is recommended before using CSF in studies.
Assay Specifications
| MRD | 8X |
| Diluted Sample Volume | 1 µL |
| LOD (fg/mL) | 20.0 |
| fLLOQ (fg/mL) | 160 |
| Spike-recovery (% recovery) | 107% |
| Linearity (% recovery) | 95.6% |
| Intra-plate CV (AVG%) | 3.6% |
| Inter-plate CV (AVG%) | 5.5% |
| EDTA Plasma Quantifiability | 100% |
Designed to Expand What Is Possible in Mouse pTau 217 Studies
Preserve limited mouse EDTA plasma and CSF samples for sample-limited preclinical studies.
Support preclinical Alzheimer’s disease research with sensitive mouse pTau 217 measurement.
Enable study designs that evaluate mouse pTau 217 changes across multiple timepoints.
Generate more biomarker data from each animal and support study designs that may reduce reliance on larger terminal cohorts.
Some workflows adapt human pTau 217 assays for mouse sample testing. SPEAR UltraDetect™ Mouse pTau 217 is designed for mouse sample analysis and uses a mouse-optimized assay diluent.
This supports improved matrix compatibility, parallelism, and dilution linearity in mouse samples, helping researchers generate reliable pTau 217 measurements in low-volume preclinical studies.
Planning a Mouse pTau 217 Study?
Connect with Spear Bio to discuss your sample type, sample volume, study timeline, and preclinical biomarker goals.
