Resource Category: Application Notes

Automating SPEAR UltraDetect™ Assays: Enhancing Precision and Throughput with the F.A.S.T. Liquid Handler

The SPEAR UltraDetect assay is a next-generation, homogeneous immunoassay platform designed for ultrasensitive protein detection using Successive Proximity Extension Amplification Reaction (SPEAR) technology. Its two-factor authentication mechanism—requiring sustained co-localization of two target-specific DNA-conjugated antibodies—delivers exceptional specificity, minimizes background noise, and achieves attomolar sensitivity with sub-µL sample volumes. To fully support this high-sensitivity workflow, automation is […]

SPEAR UltraDetect™ BD-pTau 217 Assay

Plasma pTau 217 is one of the strongest blood biomarkers for Alzheimer’s disease (AD), but emerging evidence shows circulating pTau 217 is not exclusively brain-derived. Peripheral conditions and physiological confounders can impact total plasma measurements — particularly in early-stage and screening populations. The SPEAR UltraDetect™ BD-pTau 217 Assay was developed to preferentially detect CNS-derived, low–molecular-weight […]

SPEAR UltraDetect™ Parallel Plex Solution

SPEAR UltraDetect™ Parallel Plex Solution Ultra-Performance Biomarker Detection in a New Dimension of Flexibility and Power Multiplex-like efficiency. Singleplex–grade precision. The SPEAR UltraDetect™ Parallel Plex Solution introduces a novel approach for concurrent biomarker detection without compromising analytical performance. Leveraging the platform’s minimal sample volume requirement and automated workflow, the parallel plex method enables simultaneous yet […]

SPEAR UltraDetect GFAP/NF-L app note

pTau 231 Application Note

Successive Proximity Extension Amplification Reaction (SPEAR) and its two-factor authentication mechanism

SPEAR assay precision with F.A.S.T.™ automation: UltraDetect™ Nf-L 

Dried blood spot samples used for SARS-CoV-2 neutralizing antibody measurement with ultrasensitive NAB-Sure™

NAB-Sure™, an ultrasensitive alternative to cell-based assays for precise SARS-CoV-2 neutralizing antibody measurement